28,974 research outputs found
Pulse Width Modulation for Speeding Up Quantum Optimal Control Design
This paper focuses on accelerating quantum optimal control design for complex
quantum systems. Based on our previous work [{arXiv:1607.04054}], we combine
Pulse Width Modulation (PWM) and gradient descent algorithm into solving
quantum optimal control problems, which shows distinct improvement of
computational efficiency in various cases. To further apply this algorithm to
potential experiments, we also propose the smooth realization of the optimized
control solution, e.g. using Gaussian pulse train to replace rectangular
pulses. Based on the experimental data of the D-Norleucine molecule, we
numerically find optimal control functions in -qubit and -qubit systems,
and demonstrate its efficiency advantage compared with basic GRAPE algorithm
On compression rate of quantum autoencoders: Control design, numerical and experimental realization
Quantum autoencoders which aim at compressing quantum information in a
low-dimensional latent space lie in the heart of automatic data compression in
the field of quantum information. In this paper, we establish an upper bound of
the compression rate for a given quantum autoencoder and present a learning
control approach for training the autoencoder to achieve the maximal
compression rate. The upper bound of the compression rate is theoretically
proven using eigen-decomposition and matrix differentiation, which is
determined by the eigenvalues of the density matrix representation of the input
states. Numerical results on 2-qubit and 3-qubit systems are presented to
demonstrate how to train the quantum autoencoder to achieve the theoretically
maximal compression, and the training performance using different machine
learning algorithms is compared. Experimental results of a quantum autoencoder
using quantum optical systems are illustrated for compressing two 2-qubit
states into two 1-qubit states
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 2: androgen-receptor cofactors and bypass pathways
Prostate cancer is the second leading cause of cancer related deaths in men from the western world. Treatment of prostate cancer has relied on androgen deprivation therapy for the past 50 years. Response rates are initially high (70-80%), however almost all patients develop androgen escape and subsequently die within 1-2 years. Unlike breast cancer, alternative approaches (chemotherapy and radiotherapy) do not increase survival time. The high rate of prostate cancer mortality is therefore strongly linked to both development of androgen escape and the lack of alternate therapies. AR mutations and amplifications can not explain all cases of androgen escape and post-translational modification of the AR has become an alternative theory. However recently it has been suggested that AR co-activators e.g. SRC-1 or pathways the bypass the AR (Ras/MAP kinase or PI3K/Akt) may stimulated prostate cancer progression independent of the AR. This review will focus on how AR coactivators may act to increase AR transactivation during sub-optimal DHT concentrations and
also how signal transduction pathways may promote androgen escape via activation of transcription factors, e.g. AP-1, c-Myc and Myb, that induce cell proliferation or inhibit apoptosis
Deep Adaptive Attention for Joint Facial Action Unit Detection and Face Alignment
Facial action unit (AU) detection and face alignment are two highly
correlated tasks since facial landmarks can provide precise AU locations to
facilitate the extraction of meaningful local features for AU detection. Most
existing AU detection works often treat face alignment as a preprocessing and
handle the two tasks independently. In this paper, we propose a novel
end-to-end deep learning framework for joint AU detection and face alignment,
which has not been explored before. In particular, multi-scale shared features
are learned firstly, and high-level features of face alignment are fed into AU
detection. Moreover, to extract precise local features, we propose an adaptive
attention learning module to refine the attention map of each AU adaptively.
Finally, the assembled local features are integrated with face alignment
features and global features for AU detection. Experiments on BP4D and DISFA
benchmarks demonstrate that our framework significantly outperforms the
state-of-the-art methods for AU detection.Comment: This paper has been accepted by ECCV 201
Quantum Optimal Control without Arbitrary Waveform Generators
Simple, precise, and robust control is demanded for operating a large quantum
information processor. However, existing routes to high-fidelity quantum
control rely heavily on arbitrary waveform generators that are difficult to
scale up. Here, we show that arbitrary control of a quantum system can be
achieved by simply turning on and off the control fields in a proper sequence.
The switching instances can be designed by conventional quantum optimal control
algorithms, while the required computational resources for matrix exponential
can be substantially reduced. We demonstrate the flexibility and robustness of
the resulting control protocol, and apply it to superconducting quantum
circuits for illustration. We expect this proposal to be readily achievable
with current semiconductor and superconductor technologies, which offers a
significant step towards scalable quantum computing
Groundwater and climate change: threats and opportunities
The important role of groundwater in adaptation to climate change is explored, and the competing threats and opportunities that climate change pose to groundwater systems are evaluated. This has been achieved through a review of current thinking on the complex interactions between human activities, climate and the hydrological cycle affecting groundwater quantity and quality, across different regions and time scales
IFN-gamma is associated with risk of Schistosoma japonicum infection in China.
Before the start of the schistosomiasis transmission season, 129 villagers resident on a Schistosoma japonicum-endemic island in Poyang Lake, Jiangxi Province, 64 of whom were stool-positive for S. japonicum eggs by the Kato method and 65 negative, were treated with praziquantel. Forty-five days later the 93 subjects who presented for follow-up were all stool-negative. Blood samples were collected from all 93 individuals. S. japonicum soluble worm antigen (SWAP) and soluble egg antigen (SEA) stimulated IL-4, IL-5 and IFN-gamma production in whole-blood cultures were measured by ELISA. All the subjects were interviewed nine times during the subsequent transmission season to estimate the intensity of their contact with potentially infective snail habitats, and the subjects were all re-screened for S. japonicum by the Kato method at the end of the transmission season. Fourteen subjects were found to be infected at that time. There was some indication that the risk of infection might be associated with gender (with females being at higher risk) and with the intensity of water contact, and there was evidence that levels of SEA-induced IFN-gamma production were associated with reduced risk of infection
Surface modification effects on nanocellulose - molecular dynamics simulations using umbrella sampling and computational alchemy
Topochemical modification of nanocellulose particles, in particular acetylation, is commonly used to reduce hygroscopicity and improve their dispersibility in non-polar polymers. Despite enormous experimental efforts on cellulose surface modification, there is currently no comprehensive model which considers both (a) the specific interactions between nanocellulose particles and the surrounding liquid or polymer matrix, and (b) the interactions between the particles themselves. The second mechanism is therefore frequently ignored. The present approach is based on atomistic molecular dynamics (MD) simulations, where computational alchemy is used to calculate the changes in interactions between nanocellulose and the surrounding medium (liquid or polymer) upon modification. This is combined with another method, based on potential of mean force, to calculate interactions between particles. Results show that both contributions are of equal importance for nanoparticle surface acetylation effects. The proposed method is not restricted to either cellulose or acetylation, and has the prospect to find application in a broad context of nanomaterials design
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